Tuesday, August 24, 2010

Downloads and vids.

Seattle based, U.S.F: Branss

House music from 1989 Marshall Jefferson aka Virgo: Do You Know Who You Are?

Minneapolis based, Love Lake: Ghost

Another one from Love Lake: Curses


Italian band, Drink to Me:

New Flying Lotus video:

Ontario, CN based Mathemagic

Mathemagic - Breaststroke from EyeBodega on Vimeo.

Sunday, August 22, 2010

Ithaca Music

If you have not heard Hank Roberts and his cello then check these out. Old 1988 footage from Berlin with Joey Baron (dr) and Bill Frisell (g) and others.



2007, Chapterhouse, Ithaca, NY

Tuesday, August 17, 2010

Savory Jazz Collection

The National Jazz Museum has begun the digitization process of the old Savory collection, named after the 1930s audio engineer, William Savory. The NY Times has a great piece documenting the process. Looks like these recordings had gone unheard for 70 years! Regarding the actual recording technology, money quote:

Part of what makes the Savory collection so alluring and historically important is its unusual format. At the time Savory was recording radio broadcasts for his own pleasure, which was before the introduction of tape, most studio performances were issued on 10-inch 78-r.p.m. shellac discs, which, with their limited capacity, could capture only about three minutes of music.

But Mr. Savory had access to 12- or even 16-inch discs, made of aluminum or acetate, and sometimes recorded at speeds of 33 1/3 r.p.m. That combination of bigger discs, slower speeds and more durable material allowed Mr. Savory to record longer performances in their entirety, including jam sessions at which musicians could stretch out and play extended solos that tested their creative mettle.

“Most of what exists from this era was done at home by young musicians or fans, and so you get really bad-sounding recordings,” Mr. Schoenberg said. “The difference with Bill Savory is that he was both a musician and a technical genius. You hear some of this stuff and you say, ‘This can’t be 70 years old.’ ”


Monday, August 16, 2010

Oscillations and Brain Networks

One of the areas of study in neuroscience which has grown a lot in recent years is the study of brain network oscillations and their role in sensory coding and their behavioral correlates. A recent study in Neuron by Akem and Kullmann (sweet video abstract) suggests that the brain may act like an AM Radio to allow for functional sensory coding. I hope to post more on brain rhythms, sensory coding, and behavioral state, particularly as it relates to my research and to other work being in doing in the lab, in the coming months.

A Historian Remembered

Tony Judt, a Professor of History at NYU and perhaps one of the most important contemporary European historians and political critics passed away earlier this month. I believe the Guardian's obit is most imformative of the major new outlets. Prior to his death from the effects amyotrophic lateral sclerosis, the majority of his writing consisted of a series of essays for the New York Review of Books and which culminated in a new and final book published earlier this year, Ill Fares the Land, which I am currently reading. Here he is on Charlie Rose discussing his 2005 book, Postwar, which I voraciously ingested last summer.

Psychedlic Aliens coming soon!

From Voodoo Funk/Academy Records

End of Summer Music Dump

Haven't posted anything for a while. Let's start this back up right with new music. (Right click the song title to save)

Staight outta Denver,Married in Berdichev: Wait

New Deerhunter: Revival

Two from SLEEP ∞ OVER: Outer Limits and La Rose

This is my favorite. Panda Bear: Untitled (Live at Primavera Sound 2010)

His other new track Benefica, uses a futbol crowd as a sample.

Monday, May 24, 2010

Can't go wrong with the Liberal Media...

NPRMusic has really been excellent lately...

Streaming the New Ratatat album, LP4

and a conversation with Keith Jarrett and Charlie Haden...

Excellent stuff.

Friday, April 23, 2010

Smack

"The band were as if you got Franz Ferdinand or The Monochrome Set and gave them a Mormon makeover."


Tony Buzzcock describing Vampire Weekend from Coachella

Saturday, April 10, 2010

Mixes.

DJ Ripley has a huge mix up at Sound Cloud.

Killer set, by Kon and Amir brought to you by the folks over at FutureBoogie

Monday, November 16, 2009

Bird Brains

The concept of migration and perceivable cues related to the execution of migratory behavior have been on my mind as of late. This report is pretty rad.

Monday, August 31, 2009

First neuro...now the rhythms

Over at his blog at The Atlantic, Hua Hsu posts this sick amateur rap video



Thought it would be a good second post for a blog with this name.

Let's talk pot.

THC, and its botanical vehicle, marijuana are all over the press this week. The LA Times has produced a story describing the cultural landscape surrounding the normalization of pot.
At fashion-insider parties, joints are passed nearly as freely as hors d'oeuvres. Traces of the acrid smoke waft from restaurant patios, car windows and passing pedestrians on the city streets -- in broad daylight. Even the art of name-dropping in casual conversation -- once limited to celebrity sightings and designer shoe purchases -- now includes the occasional boast of recently discovered weed strains such as "Strawberry Cough" and "Purple Kush."

Public sentiment is more than anecdotal; earlier this year, a California Field Poll found that 56% of California voters supported legalizing and taxing marijuana. Last month, voters in Oakland overwhelmingly approved a tax increase on medical marijuana sales, the first of its kind in the country, and Los Angeles Councilwoman Janice Hahn has proposed something similar for the City of Angels. "In this current economic crisis, we need to get creative about how we raise funds," Hahn said in a statement.

Smoking pot used to be the kind of personal conduct that could sink a U.S. Supreme Court nomination (Douglas H. Ginsburg in 1987) and embarrass a presidential candidate (Bill Clinton in 1992). Today, it seems to be a non-issue for the current inhabitant of the Oval Office; Barack Obama issued his marijuana mea culpa in a 1995 memoir.


This, I believe is an irreversible process and actually a GOOD thing. Study after study has shown that marijuana's neuroactive components, cannabinoids are far less toxic than other recreational drugs. Also recently it has been shown that cannabinoids may have a neuroprotective effect. To me it is a sign of greater cultural sanity for a society to really come to its senses with regards to marijuana.

That being said, our current state of knowledge of the neurobiological mechanisms underlying marijuana's obvious behavioral effects is far from complete, which makes the report by Puighermanal et. al in this month's issue of Nature Neuroscience so important. For the first time, researchers have been able to provide an explanation for THC-induced amnesia at the cellular level. THC activates CB1 receptors leading to an increase in mTOR activity, a protein kinase that is highly involved in cell growth, proliferation, and protein synthesis. Using first an inhibitor of mTOR, rapamycin (the reason mTOR is called what it is-- Mammalian Target Of Rapamycin) and later an inhibitor of protein synthesis, anisomycin, the researchers found that the cognitive deficits accompanying THC dosing were abolished. Protein synthesis is highly energy intensive for cells and an imbalance of protein synthesis has been reported in cases of mental retardation, including genetic disorders related to autism.

This imbalance in protein translation is the end result of a network wide imbalance of excitation and inhibition. GABA is the dominant inhibitory neurotransmitter in the brain. CB1 receptors lead to inhibition of neurotransmitter release from which ever cell they are found on. Importantly CB1 receptors are found on GABAergic hippocampal neurons in numbers nearly 40 times as large as glutamatergic neurons. Widespread hippocampal activation of GABAergic CB1 receptor-positive neurons leads to a decrease in inhibitory tone, producing a relative increase in excitatory glutamatergic tone. Increased glumatergic activity leads to increased protein synthesis mediated by the all important NMDA receptor.

The paper gets pretty complicated and they used many different mice knockouts to get at their data, but the end result is that THC-induced amnesia in mice, and its human analog, "weed memory", is due to the temporary imbalance of protein synthesis due to a temporary imbalance of excitatory and inhibitory activity in the hippocampus.



Citation:

Puighermanal, E., Marsicano, G., Busquets-Garcia, A., Lutz, B., Maldonado, R., & Ozaita, A. (2009). Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling Nature Neuroscience, 12 (9), 1152-1158